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Proposed mechanism of action of the mTORC1-inhibitor everolimus. Everolimus inhibits the mTORC1 complex and thereby down-regulates the mTORC1/p70S6K signaling cascade, preventing the cell from cell cycle progression, survival and proliferation. Inhibition of mTORC1/p70S6K leads to disinhibition/activation of IRS-1 and thereby activation of PI3K/Akt, which in turn inhibits GSK3 by phosphorylation.
