Table 1.

Summary of the most highly expressed genes in replicative senescent cells identified by microarray

Gene	Description	Fold change in replicative senescent cells
WNT16	Wingless-type MMTV integration site, member 16	6.3
MMP10	Matrix metalloproteinase 10 (stromelysin 2)	6.3
MMP3	Matrix metalloproteinase 3 (stromelysin 1)	5.0
CDKN1A	CDK inhibitor 1A (p21, Waf1, Cip1)	3.4
PERP	TP53 apoptosis effector	2.7
WIG1	p53 target zinc finger protein	2.2

NOTE: See Supplementary Tables S1–S3 for complete list. Data deposited in NCBI’s Gene Expression Omnibus as GSE15919.