1.

RA患者一般情况及临床特征(n=803)

Clinical and demographic features of all participants (n=803)

Items	Total (n=803)	Family history of rheumatic disease
		No (n=680)	Yes (n=123)	P
RA, rheumatoid arthritis; MDHAQ, multi-dimensional health assessment questionnaire; VAS, visual analogue scale; TJC, tender joint count; SJC, swollen joint count; DJC, deformity joint count; BMI, body mass index; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; DAS28, disease activity score in 28 joints; CCP, cyclic citrullinated peptide; RF, rheumatoid factor.
Female,n (%)	624 (77.71)	519 (76.32)	105 (85.37)	0.05
Han nationality,n (%)	715 (95.72)	614 (96.39)	101 (91.82)	0.03
Age/years, x±s	55.53±13.52	56.20±13.39	51.86±13.69	<0.01
Age at RA onset/years, x±s	45.09±14.50	46.01±14.46	39.97±13.68	<0.01
History of smoking, n (%)	222 (31.94)	185 (31.46)	37 (34.58)	0.53
History of drinking, n (%)	210 (27.23)	178 (27.30)	32 (26.89)	0.93
Disease duration/years, M (P25, P75)	7.00 (3.00,15.00)	7.00 (3.00,14.00)	10.00 (3.00, 16.00)	0.12
MDHAQ, M (P25, P75)	2.0 (0.0, 6.0)	2.0 (0.0, 6.0)	2.0 (0.0, 6.0)	0.32
Pain VAS, M (P25, P75)	3.0 (1.0, 6.0)	3.0 (1.0, 5.0)	3.0 (1.0, 6.0)	0.15
TJC,M (P25, P75)	2.0 (0.0, 6.0)	2.0 (0.0, 6.0)	2.0 (0.0, 6.0)	0.73
SJC,M (P25, P75)	1.0 (0.0, 4.0)	1.0 (0.0, 4.0)	2.0 (0.0, 4.0)	0.37
DJC,M (P25, P75)	0.0 (0.0, 4.0)	0.0 (0.0, 4.0)	1.0 (0.0,7.0)	0.15
BMI/(kg/m2), x±s	23.22±3.50	23.35±3.47	22.47±3.61	0.05
CRP/(mg/L),M (P25, P75)	4.68 (1.85, 11.72)	4.88 (2.00, 12.03)	3.40 (1.53, 10.54)	0.07
ESR/(mm/h), M (P25, P75)	19.0 (10.0, 37.8)	19.0 (11.0, 39.0)	17.0 (8.3, 29.5)	0.05
DAS28-CRP,M (P25, P75)	3.1 (2.2, 4.1)	3.0 (2.2, 4.1)	3.1 (2.1, 4.2)	0.96
DAS28-ESR,M (P25, P75)	3.6 (2.7, 4.7)	3.6 (2.7, 4.7)	3.3 (2.5, 4.5)	0.17
Anti-CCP positive, n (%)	509 (85.55)	441 (85.96)	68 (82.93)	0.47
RF-positive, n (%)	394 (68.28)	332 (66.67)	62 (78.48)	<0.05