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. 2020 Aug 13;14:251. doi: 10.3389/fncel.2020.00251

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Copyright © 2020 Zuo, Yin, Cheng, Li, Wu, Liu, Gu and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of elamipretide on pyroptosis and neuroinflammation in the hippocampus in aged mice after surgery. (A) Representative western blotting and quantitative analysis of protein levels of the full-length Gasdermin D (GSDMD) and GSDMD-N domain (GSDMD-ND) in the hippocampus in aged mice. (B) Western blotting analyses of IL-1β and IL-18 levels. (C) Enzyme-linked immunosorbent assay (ELISA) analyses of IL-1β and IL-18 levels. Values are presented as mean ± SEM (n = 6 mice/group). *p < 0.05 vs. the Veh group; ^#p < 0.05 vs. the Sur group.