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Elamipretide attenuates surgery-induced cognitive deficits in aged mice. (A) Total distance traveled and (B) time spent in the center in open field tests. The open field tests in aged mice were performed on postoperative day 7. (C) Freezing time to context and (D) freezing time to tone in the fear conditioning tests. Values are presented as mean ± SEM (n = 12 mice/group). *p < 0.05 vs. the Veh group; #p < 0.05 vs. the Sur group.
