Figure 8.

Characterization of VG remodeling of the JVs in which mature ECs were genetically labeled with YFP transplanted to the CAs of WT mice. (A) Schematic presentation of the reporter JVs grafted into the CAs of WT mice. Total number of VGs is 15 and 11 of them are VGs with severe NI formation (VG-S). (B) The percentages of SMA, YFP and SMA and YFP double positive cells in each major layer of VGs of VG-S (n=3). (C) The representative images of co-staining of YFP and SMA as well as co-staining of YFP and vWF in the cross-sections of #1 segment at the proximal end, #3–#7 segments at the middle part, and #9 segment at the distal end of VGs. YFP is green; SMA and vWF are red. White dotted lines separate the NI and the Ad layers. The abbreviations are described in Figures 1 and 2.