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. 2020 Aug 3;5(32):19960–19967. doi: 10.1021/acsomega.0c01121

Figure 4.

Figure 4

α-MG reverses cisplatin-induced PI3K/Akt suppression and JNK activation. (A) Western blotting analysis of PI3K, p-PI3K, Akt, and p-Akt proteins. (B) Quantitative analysis of PI3K/Akt. (C) Time course of activation of JNK caused by cisplatin. (D) α-MG suppressed the expression of JNK in a dose-dependent manner. (E, F) Quantitative analysis of p-JNK. All data are represented as means ± SD; *p < 0.05, **p < 0.01 compared to the control group; #p < 0.05, ##p < 0.01 compared with the cisplatin group.