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. Author manuscript; available in PMC: 2020 Aug 20.
Published in final edited form as: Surgery. 2018 Feb 15;163(6):1238–1244. doi: 10.1016/j.surg.2018.01.004

Table 3.

Characteristics of patients with observed cure and probability of cure estimated from the semiparametric mixture cure model.

All Patients Observed Cure* Probability of Cure Ɨ
Total Number % of Patients %
1211 250 20.6% -
Synchronous 491 96 19.6% 22.5%
Metachronous 720 154 21.4% 27.8%
Node-Positive Primary 727 121 16.6% 21.4%
 N1 466 82 17.6% 21.1%
 N2 261 39 14.9% 20.3%
Node-Negative Primary 473 128 27.1% 30.0%
Preoperative CEA >200 119 11 9.2% 11.4%
Preoperative CEA ≤200 936 217 23.2% 25.7%
DFI <12 months 637 121 19.0% 23.4%
DFI ≥12 months 574 129 22.5% 24.9%
No. of hepatic tumors
 Median 2 1
 1 588 134 22.8% 24.3%
 2 to 4 477 100 21.0% 25.8%
 5 to 10 115 15 13.0% 15.1%
 >10 31 1 3.2% 11.7%
Largest Hepatic Tumor >5cm 399 58 14.5% 18.6%
Largest Hepatic Tumor ≤5cm 812 192 23.6% 26.7%
Largest tumor, median cm 4.0cm 3.25cm
Extrahepatic Disease 88 7 8.0% 10.4%
No Extrahepatic Disease 1123 243 21.6% 25.2%
Fong Score
 <2 627 165 26.3% 27.2%
 ≥3 420 63 15.0% 17.7%
Resection ≥3 segments 771 145 18.8% 25.2%
Perioperative HAIP 348 105 30.2% 29.5%
No Perioperative HAIP 863 145 16.8% 21.3%
Perioperative Chemo 1120 234 20.9% 24.6%
No Perioperative Chemo 91 16 17.6% 23.0%
Margin positive 109 9 8.3% 8.0%
Margin negative 1102 241 21.9% 27.2%

Note:

*

Observed Cure defined as 10-year survival with either no recurrence or resected recurrence with at least 3 years of disease-free follow-up,

Ɨ

Probability of cure was estimated from semiparametric mixture cure models