Table 3.
All Patients | Observed Cure* | Probability of Cure Ɨ | ||
---|---|---|---|---|
Total | Number | % of Patients | % | |
1211 | 250 | 20.6% | - | |
Synchronous | 491 | 96 | 19.6% | 22.5% |
Metachronous | 720 | 154 | 21.4% | 27.8% |
Node-Positive Primary | 727 | 121 | 16.6% | 21.4% |
N1 | 466 | 82 | 17.6% | 21.1% |
N2 | 261 | 39 | 14.9% | 20.3% |
Node-Negative Primary | 473 | 128 | 27.1% | 30.0% |
Preoperative CEA >200 | 119 | 11 | 9.2% | 11.4% |
Preoperative CEA ≤200 | 936 | 217 | 23.2% | 25.7% |
DFI <12 months | 637 | 121 | 19.0% | 23.4% |
DFI ≥12 months | 574 | 129 | 22.5% | 24.9% |
No. of hepatic tumors | ||||
Median | 2 | 1 | ||
1 | 588 | 134 | 22.8% | 24.3% |
2 to 4 | 477 | 100 | 21.0% | 25.8% |
5 to 10 | 115 | 15 | 13.0% | 15.1% |
>10 | 31 | 1 | 3.2% | 11.7% |
Largest Hepatic Tumor >5cm | 399 | 58 | 14.5% | 18.6% |
Largest Hepatic Tumor ≤5cm | 812 | 192 | 23.6% | 26.7% |
Largest tumor, median cm | 4.0cm | 3.25cm | ||
Extrahepatic Disease | 88 | 7 | 8.0% | 10.4% |
No Extrahepatic Disease | 1123 | 243 | 21.6% | 25.2% |
Fong Score | ||||
<2 | 627 | 165 | 26.3% | 27.2% |
≥3 | 420 | 63 | 15.0% | 17.7% |
Resection ≥3 segments | 771 | 145 | 18.8% | 25.2% |
Perioperative HAIP | 348 | 105 | 30.2% | 29.5% |
No Perioperative HAIP | 863 | 145 | 16.8% | 21.3% |
Perioperative Chemo | 1120 | 234 | 20.9% | 24.6% |
No Perioperative Chemo | 91 | 16 | 17.6% | 23.0% |
Margin positive | 109 | 9 | 8.3% | 8.0% |
Margin negative | 1102 | 241 | 21.9% | 27.2% |
Note:
Observed Cure defined as 10-year survival with either no recurrence or resected recurrence with at least 3 years of disease-free follow-up,
Probability of cure was estimated from semiparametric mixture cure models