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. Author manuscript; available in PMC: 2020 Aug 20.
Published in final edited form as: Handb Exp Pharmacol. 2017;240:21–46. doi: 10.1007/164_2016_5

Table 1.

Electrophysiological properties of the PTP and ATP synthase

Preparation Conductance Selectivity Rectification Reference
PTP
I MM, patch clamping, induced by cuprizone ~100pS Slight anion selectivity Not determined Sorgato et al. (1987)
Mitoplast. patch clamping Multiple conductances (30 pS to 1.3 nS) Slight anion selectivity Positive rectification at positive potentials and negative rectification at negative potentials Petronilli et al. (1989)
Mitoplast, patch clamping (mitochondrial muhiconductance channel) Multiple conductances (10 pS to 1 nS) Slight cation selectivity Variable rectification at positive and negative potentials Kinnally et al. (1989)
ATP synthase
ATP synthase dimers in lipid bilayers Peak conductance of 1-1.3 nS with multiple subconductance states Not determined Not determined Giorgio et al. (2013)
ATP synthase monomers in liposomes, patch clamping Multiple conductances (-800 pS) Not determined Not determined Alavian et al. (2014)
Purified ATP synthase c-subunits in lipid bilayers Multiple conductances (15 pS to 2 nS) Relative cation selectivity Not tested Azarashvili et al. (2014)
Purified ATP synthase c-subunits in liposomes, patch clamping Multiple conductances (lOOpS to 2 nS) Slight cation selectivity Slightly negative rectification Alavian et al. (2014)