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. 2020 Jul 17;6(29):eaba8105. doi: 10.1126/sciadv.aba8105

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 1 — (A) Local resolution of the OlCALHM1_EM structure, estimated by RELION. (B and C) Overall structure of the OlCALHM1_EM octamer, viewed parallel to the membrane (B) and from the extracellular side (C). (D) Subunit structure of OlCALHM1_EM, viewed parallel to the membrane. Each region is colored as follows: NTH, pink; TM1, purple; EL1, white; TM2a, light blue; TM2b, IL1, and TM3a, cyan; TM3b and 3c, light green; EL2, yellow; TM4, orange; CTH, red. The N and C termini are indicated by “N” and “C,” respectively. (E) Schematic representation of the OlCALHM1 membrane topology, colored as in (D). (F to H) Close-up views of the intracellular side (F), the two disulfide bonds in the extracellular region (G), and the interactions between TM1 and the other TMs around Asp¹²⁰ (H).