TABLE 3.
Diagnostic sensitivity and specificity of CBC parameters in study subjects
| AUC (95% CI) | Sensitivity (%) (95% CI) | Specificity (%) (95% CI) | +LR (95% CI) | ‐LR (95% CI) | PPV (%) (95% CI) | NPV (%) (95% CI) | Cutoff value | |
|---|---|---|---|---|---|---|---|---|
| HGB | 0.604 (0.548‐0.658) | 36.2 (27.0‐46.1) | 83.3 (77.6‐88.1) | 2.17 (1.5‐3.2) | 0.77 (0.7‐0.9) | 14.2 (10.1‐19.8) | 94.5 (93.6‐95.2) | >119 |
| HCT | 0.591 (0.538‐0.650) | 51.4 (41.5‐61.3) | 69.1 (62.3‐75.2) | 1.66 (1.3‐2.2) | 0.7 (0.6‐0.9) | 11.3 (8.8‐14.3) | 94.9 (93.7‐95.9) | >34.2 |
| MPV | 0.569 (0.512‐0.624) | 61.0 (50.9‐70.3) | 51.9 (44.9‐58.8) | 1.27 (1.0‐1.6) | 0.75 (0.6‐1.0) | 8.8 (7.3‐10.7) | 94.6 (93.0‐95.8) | >10 |
| PDW | 0.588 (0.531‐0.643) | 60.0 (50.0‐69.4) | 55.7 (48.7‐62.5) | 1.35 (1.1‐1.7) | 0.72 (0.6‐0.9) | 9.4 (7.7‐11.4) | 94.8 (93.3‐96.0) | >11.2 |
| Lym | 0.598 (0.541‐0.652) | 68.6 (58.8‐77.3) | 49.5 (42.6‐56.5) | 1.36 (1.1‐1.6) | 0.63 (0.5‐0.9) | 9.4 (7.9‐11.1) | 95.4 (93.8‐96.6) | ≤1.95 |
| PLR | 0.575 (0.519‐0.630) | 74.3 (64.8‐82.3) | 41.4 (34.7‐48.4) | 1.27 (1.1‐1.5) | 0.62 (0.4‐0.9) | 8.8 (7.6‐10.2) | 95.5 (93.6‐96.8) | >108.17 |
| LMR | 0.615 (0.559‐0.669) | 31.4 (22.7‐41.2) | 87.1 (81.8‐91.4) | 2.44 (1.6‐3.8) | 0.79 (0.7‐0.9) | 15.7 (10.6‐22.7) | 94.3 (93.5‐95.0) | ≤2.31 |
| NLR | 0.625 (0.569‐0.679) | 78.1 (69.0‐85.6) | 46.2 (39.3‐53.2) | 1.45 (1.2‐1.7) | 0.47 (0.3‐0.7) | 10 (8.6‐11.5) | 96.5 (94.9‐97.6) | >3.56 |
| Combined marker | 0.672 (0.618‐0.724) | 88.6 (80.9‐94.0) | 40.5 (33.8‐47.4) | 1.49 (1.3‐1.7) | 0.28 (0.2‐0.5) | 10.2 (9.1‐11.5) | 97.9 (96.4‐98.8) | >0.25 |