TABLE 2.
Association between H19 gene rs2839698 polymorphism and colorectal cancer risk determined by logistic regression analyses
| Models | Genotype | Case (n, %) | Control (n, %) | OR (95% CI) | P‐value | OR (95% CI)* | P‐value* |
|---|---|---|---|---|---|---|---|
| Co‐dominant | GG | 134 (42.7%) | 154 (35.1%) | 1.00 | ‐ | 1.00 | ‐ |
| Heterozygote | GA | 140 (44.6%) | 211 (48.1%) | 0.77 (0.56‐1.05) | .098 | 0.72 (0.50‐1.02) | .062 |
| Homozygote | AA | 40 (12.7%) | 74 (16.9%) | 0.62 (0.40‐0.97) | .038 | 0.63 (0.38‐1.02) | .062 |
| Dominant | GG | 134 (42.7%) | 154 (35.1%) | 1.00 | ‐ | 1.00 | ‐ |
| AA + GA | 180 (57.3%) | 285 (64.9%) | 0.73 (0.54‐0.98) | .037 | 0.69 (0.50‐0.96) | .030 | |
| Recessive | GA + GG | 274 (87.3%) | 365 (83.1%) | 1.00 | ‐ | 1.00 | ‐ |
| AA | 40 (12.7%) | 74 (16.9%) | 0.72 (0.47‐1.09) | .118 | 0.75 (0.48‐1.18) | .214 | |
| Allele | G | 408 (65.0%) | 519 (59.1%) | 1.00 | ‐ | ‐ | ‐ |
| A | 220 (35.0%) | 359 (40.9%) | 0.78 (0.63‐0.96) | .021 | ‐ | ‐ |
The genotyping was successful in 314 cases and 439 controls for rs2839698 polymorphism; Bold values are statistically significant (P < .05).
*
Adjustment for age, sex, BMI, alcohol, and smoking.