TABLE 3.
Analysis of factors predicting DFS
| Items | Cox's proportional hazard regression model | |||
|---|---|---|---|---|
| P value | HR | 95% CI | ||
| Lower | Higher | |||
| Univariate Cox's regression | ||||
| Circ_0018289 high | .006 | 2.198 | 1.254 | 3.853 |
| Age (≥45 y) | .168 | 1.462 | 0.852 | 2.508 |
| HPV positive | .641 | 0.859 | 0.453 | 1.628 |
| Histological type | .477 | 0.845 | 0.530 | 1.346 |
| Higher pathological grade | <.001 | 2.655 | 1.771 | 3.980 |
| Tumor size (≥4 cm) | .011 | 1.998 | 1.173 | 3.405 |
| Lymph node metastasis | .005 | 2.231 | 1.281 | 3.884 |
| Higher FIGO stage | <.001 | 3.315 | 1.903 | 5.775 |
| Backward stepwise multivariate Cox's regression | ||||
| Circ_0018289 high | .042 | 1.816 | 1.022 | 3.226 |
| Higher pathological grade | <.001 | 2.172 | 1.428 | 3.303 |
| Higher FIGO stage | .023 | 2.008 | 1.100 | 3.666 |
Factors predicting DFS were analyzed by univariate and backward stepwise multivariate Cox's proportional hazard regression model.
Abbreviations: CI, confidence interval; DFS, disease‐free survival; FIGO, International Federation of Gynecology and Obstetrics; HPV, human papillomavirus; HR, hazard ratio.