TABLE 4.
Analysis of factors predicting OS
| Items | Cox's proportional hazard regression model | |||
|---|---|---|---|---|
| P value | HR | 95%CI | ||
| Lower | Higher | |||
| Univariate Cox's regression | ||||
| Circ_0018289 high | .018 | 2.265 | 1.151 | 4.457 |
| Age (≥45 y) | .222 | 1.493 | 0.785 | 2.842 |
| HPV positive | .077 | 0.544 | 0.276 | 1.069 |
| Histological type | .278 | 0.747 | 0.441 | 1.265 |
| Higher pathological grade | <.001 | 3.477 | 2.028 | 5.963 |
| Tumor size (≥4 cm) | .002 | 2.873 | 1.482 | 5.571 |
| Lymph node metastasis | .008 | 2.386 | 1.257 | 4.529 |
| Higher FIGO stage | <.001 | 4.106 | 2.050 | 8.226 |
| Backward stepwise multivariate Cox's regression | ||||
| Higher pathological grade | .001 | 2.664 | 1.531 | 4.637 |
| Tumor size (≥4 cm) | .013 | 2.337 | 1.197 | 4.562 |
| Higher FIGO stage | .019 | 2.388 | 1.155 | 4.941 |
Factors predicting OS were analyzed by univariate and backward stepwise multivariate Cox's proportional hazard regression model.
Abbreviations: CI, confidence interval; FIGO, International Federation of Gynecology and Obstetrics; HPV, human papillomavirus; HR, hazard ratio; OS, overall survival.