Table 2.
Genotype and allele frequencies of 15 SNPs in the human SOX11 gene between schizophrenia patients and controls
| No. | subjects | Allele and frequency a | χ 2 P(P b ) | OR (95% CI) | |
|---|---|---|---|---|---|
| C | T | ||||
| SNP1 | Case | 1209 (0.787) | 327 (0.213) | χ 2 = 0.9745 | 0.93 (0.79‐1.08) |
| Control | 2150 (0.800) | 538 (0.200) | p = .3236 | ||
| C | T | ||||
| SNP2 | Case | 520 (0.339) | 1016 (0.661) | χ2 = 4.7643 | 0.86 (0.76‐0.99) |
| Control | 1003 (0.372) | 1693 (0.628) | p = .0291 | ||
| A | G | ||||
| SNP3 | Case | 614 (0.400) | 922 (0.600) | χ2 = 3.3068 | 0.89 (0.78‐1.01) |
| Control | 1155 (0.428) | 1541 (0.572) | p = .0691 | ||
| G | T | ||||
| SNP4 | Case | 163 (0.106) | 1373 (0.894) | χ2 = 0.2670 | 0.95 (0.77‐1.16) |
| Control | 300 (0.111) | 2396 (0.889) | p = .6053 | ||
| A | G | ||||
| SNP5 | Case | 780 (0.508) | 756 (0.492) | χ2 = 1.8788 | 1.092 (0.96‐1.24) |
| Control | 1310 (0.486) | 1386 (0.514) | p = .1705 | ||
| G | T | ||||
| SNP6 | Case | 783 (0.510) | 753 (0.490) | χ2 = 6.9301 | 1.18 (1.04‐1.34) |
| Control | 1260 (0.468) | 1434 (0.532) | p = .0085 | ||
| A | G | ||||
| SNP7 | Case | 620 (0.404) | 914 (0.596) | χ2 = 9.3616 | 1.22 (1.07‐1.39) |
| Control | 962 (0.357) | 1734 (0.643) | p = .0022 (.033) | ||
| A | G | ||||
| SNP8 | Case | 640 (0.417) | 896 (0.583) | χ2 = 11.0119 | 1.24 (1.09‐1.41) |
| Control | 982 (0.365) | 1708 (0.635) | p = .0009 (.0135) | ||
| A | G | ||||
| SNP9 | Case | 857 (0.558) | 679 (0.442) | χ2 = 9.0128 | 1.21 (1.07‐1.38) |
| Control | 1374 (0.510) | 1320 (0.490) | p = .0027 (.0405) | ||
| G | T | ||||
| SNP10 | Case | 1117 (0.727) | 419 (0.273) | χ2 = 9.1470 | 1.23 (1.08‐1.42) |
| Control | 1841 (0.683) | 855 (0.317) | p = .0025 (.00375) | ||
| A | C | ||||
| SNP11 | Case | 1111 (0.723) | 425 (0.277) | χ2 = 7.5864 | 1.21 (1.06‐1.39) |
| Control | 1841 (0.683) | 855 (0.317) | p = .0059 | ||
| C | T | ||||
| SNP12 | Case | 1117 (0.727) | 419 (0.273) | χ2 = 6.1519 | 1.19 (1.04‐1.37) |
| Control | 1863 (0.691) | 833 (0.309) | p = .0132 | ||
| C | T | ||||
| SNP13 | Case | 911 (0.595) | 621 (0.405) | χ2 = 4.1815 | 0.87 (0.77‐0.99) |
| Control | 1689 (0.626) | 1007 (0.374) | p = .0409 | ||
| A | G | ||||
| SNP14 | Case | 869 (0.566) | 667 (0.434) | χ2 = 1.2700 | 1.08 (0.95‐1.22) |
| Control | 1477 (0.548) | 1219 (0.452) | p = .2598 | ||
| C | T | ||||
| SNP15 | Case | 1119 (0.729) | 417 (0.271) | χ2 = 0.4919 | 1.05 (0.91‐1.21) |
| Control | 1937 (0.718) | 759 (0.282) | p = .4831 | ||
Significant P values (<.05) are in boldface.
a
Frequencies are shown in parenthesis.
b
Significant P value after the strict Bonferroni correction.