Table 3.
Genotype Association of nine SNPs under different genetic models with schizophrenia
| No. | Genotype | Case a | Control a | Codominant | Dominant | Recessive | Overdominant | Log‐additive | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | P | ||||
| SNP2 |
TT CT CC |
345 (0.449) 326 (0.424) 97 (0.126) |
526 (0.390) 641 (0.476) 181 (0.134) |
1.290 (1.068‐1.558) 1.054 (0.793‐1.395) |
.0087 .7144 |
1.275 (1.064‐1.526) | .0080 | 1.073 (0.823‐1.397) | .6017 | 1.229 (1.029‐1.471) | .0234 | .0279 |
| SNP6 |
GG GT TT |
194 (0.253) 395 (0.514) 179 (0.233) |
294 (0.218) 672 (0.499) 381 (0.283) |
1.123 (0.899‐1.397) 0.799 (0.643‐0.9931) |
.3023 .0426 |
1.211 (0.985‐1.487) | .0714 | 0.771 (0.627‐0.945) | .0126 | 0.940 (0.788‐1.121) | .4947 | .0260 |
| SNP7 |
GG AG AA |
268 (0.349) 378 (0.493) 121 (0.158) |
555 (0.412) 624 (0.463) 169 (0.125) |
0.797 (0.658‐0.968) 1.182 (0.910‐1.540) |
.0218 .2180 |
0.767 (0.640‐ 0.922) | .0047 | 1.307 (1.014‐1.684) | .0374 | 0.887 (0.744 −1.058) | .1852 | .0085 |
| SNP8 |
GG AG AA |
256 (0.333) 384 (0.500) 128 (0.167) |
541 (0.402) 626 (0.465) 178 (0.132) |
0.771 (0.634‐0.938) 1.172 (0.905‐1.523) |
.0092 .2310 |
0.743 (0.617‐0.895) | .0017 | 1.311 (1.021‐1.672) | .0310 | 0.871 (0.730‐1.038) | .1259 | .0035 |
| SNP9 |
AA AG GG |
236 (0.307) 385 (0.501) 147 (0.191) |
354 (0.263) 666 (0.494) 327 (0.243) |
1.153 (0.937‐1.416) 0.778 (0.619‐0.982) |
.1770 .0331 |
1.244 (1.023‐1.513) | .0283 | 0.738 (0.594‐0.919) | .0065 | 0.973 (0.816‐1.160) | .7612 | .0097 |
| SNP10 |
GG GT TT |
401 (0.522) 315 (0.410) 52 (0.068) |
627 (0.465) 587 (0.435) 134 (0.099) |
1.192 (0.988‐1.433) 0.723 (0.5079‐1.021) |
.0638 .0673 |
1.256 (1.054‐1.499) | .0116 | 0.658 (0.474‐0.913) | .0133 | 1.109 (0.927‐1.328) | .2577 | .0083 |
| SNP11 |
AA AC CC |
394 (0.513) 323 (0.421) 51 (0.066) |
627 (0.465) 587 (0.435) 134 (0.099) |
1.142 (0.947‐1.372) 0.692 (0.484‐0.979) |
.1600 .0382 |
1.211 (1.016‐1.445) | .0340 | 0.644 (0.463‐0.897) | .0098 | 1.063 (0.889‐1.273) | .5060 | .0131 |
| SNP12 |
CC CT TT |
399 (0.520) 319 (0.415) 50 (0.065) |
647 (0.480) 569 (0.422) 132 (0.098) |
1.100 (0.912‐1.322) 0.676 (0.478‐0.963) |
.3135 .0289 |
1.172 (0.983‐1.398) | .0801 | 0.642 (0.458‐0.898) | .0096 | 1.028 (0.859‐1.230) | .7625 | .0210 |
| SNP13 |
CC CT TT |
264 (0.345) 383 (0.500) 119 (0.155) |
534 (0.396) 621 (0.461) 193 (0.143) |
0.802 (0.660‐0.974) 1.000 (0.768‐1.301) |
.0260 .9984 |
0.802 (0.667‐0.964) | .0189 | 1.101 (0.861‐1.406) | .4480 | 0.854 (0.716‐1.019) | .0818 | .0636 |
Significant P values (<.05) are in boldface.
Frequencies are shown in parenthesis.