FIG 5.

Metabolic effects on glycolysis in the absence of Gcn5p and Ubp8p. The model shows enzymes whose ubiquitylation is altered in the absence of Gcn5p and Ubp8p and possible routes redirecting glycolytic flux toward fermentation, gluconeogenesis/anaplerotic routes, or a pentose phosphate shunt according to the altered redox balance of the mutants. The partial reoxidation of the cytosolic NADH by the mitochondrial transdehydrogenase Nde1p in gcn5Δ is deduced by the contemporary presence of Adh1p and Adh2p in high glucose medium.