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A model for activation of the ATR/p-p62/GATA4 pathway by HPV to regulate expression of inflammatory genes and HPV replication. HPV E6 and E7 activate ATR, which then phosphorylates p62 that in turn induces GATA4 degradation. This results in suppression of expression of inflammatory genes and IFN-κ as well as promotion of HPV replication.
