Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 11;11(4):e01845-20. doi: 10.1128/mBio.01845-20

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Schaefer et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

PMC Copyright notice

FIG 2 — Arginase activity in C. albicans ureohydrolase mutants plus arginase and iNOS activity during the macrophage interaction. (A) Arginase activity was determined in protein extracts isolated from C. albicans cultures grown in YPD. (B) Schematic model of how C. albicans might compete for arginine in competition with macrophages, leading to suppression of NO synthesis by inducing arginase activity (based on data from reference 32). (C) Macrophage NO synthesis following costimulation with C. albicans wild-type and ureohydrolase mutant strains. (D) Macrophage-derived or total (macrophage and C. albicans) arginase activity following costimulation with C. albicans wild-type cells. (E and F) Total (E) or macrophage-derived (F) arginase activity following costimulation with C. albicans wild-type and ureohydrolase mutant strains. **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not statistically significant.