Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 11;11(4):e01704-20. doi: 10.1128/mBio.01704-20

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Chidawanyika et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

PMC Copyright notice

FIG 1 — Genes that mediate H₂O₂-induced cell death isolated from a positive-selection screen in CRISPR/Cas9-modified HAP1 cells. (A) Positive-selection screen in CRISPR/Cas9-modified HAP1 cells using 350 μM H₂O₂. KO HAP1 cell libraries generated from WT HAP1 cells that were transduced with pooled lentiCRISPR libraries were treated with 350 μM H₂O_2. Next-generation sequencing (NGS) of the genomic DNA of resistant cells and MAGeCK bioinformatic analysis identified candidate genes. (B) Identification of top candidate genes that mediate H₂O₂-induced cell death in HAP1 cells through gene scores based on RRA P values generated from MAGeCK analysis.