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. 2020 Jul 24;6(30):eabb4429. doi: 10.1126/sciadv.abb4429

Fig. 1. Design of NT-lipidoids for effective brain delivery.

Fig. 1

(A) Schematic illustration of formulating NT-lipidoid–doped LNPs for cargo delivery into the brain. (B) Synthesis route, lipid nomenclature, and chemical structure of NTs used for lipidoid synthesis. (C) Representative ex vivo fluorescence images of the dissected brain 1 hour after one-time intravenous injection of DiR-labeled NT-LNPs (1 mg/kg). DiR was doped into the NT-LNPs with a 10% weight ratio. The mice were perfused with saline before dissection.