Fig. 4. In vitro fibrin-lysis assay by a vertical-channel gel system composed of agarose-fibrin.

(A) Schematic diagrams and representative photographs of the fibrinolytic process of the agarose-fibrin gel incubated with saline, native tPA, SiO₂-tPA, and MMB-SiO₂-tPA at different thrombolysis times, respectively. (B) Quantification of fibrinolytic area of fibrin over time incubated with saline, native tPA, SiO₂-tPA, and MMB-SiO₂-tPA (n = 5; ***P < 0.001). (C) The mean fibrinolytic rate of fibrin at different time intervals incubated with native tPA, SiO₂-tPA, and MMB-SiO₂-tPA (n = 5).