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Clinical follow up. Femur x-ray before (a) and after treatment (b) with narrows indicating resolution of severe osteomyelitic lesions and (c) with an initial pustular rash in the forearms observed. The thoracic X-Ray (d) with black narrow indicating an acute osteomyelitis in the 7th rib during a flare induced by canakinumab. The figure (e) shows laboratory control of acute reactant markers before and after the treatment and the inflammation induced by the drug induced flare
