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. 2020 Aug 20;20:310. doi: 10.1186/s12883-020-01888-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Cumulative age distribution and T test of the average age at diagnosis of different types of glioma. a Cumulative age distribution of WHO I-IV grade glioma, the mean age of glioma patients increases with the WHO grade (WHO I: 21.9 years, WHO II: 33.6 years, WHO III: 38.9 years and WHO IV: 46.3 years, respectively). b The diagnosed age boxplot figure of WHO I-IV grade glioma. c Cumulative age distribution of anaplastic astrocytoma and diffuse astrocytoma, there is likely for an earlier manifestation in diffuse astrocytoma. d The average age at diagnosis of anaplastic astrocytoma and diffuse astrocytoma. e Cumulative age distribution of Oligodendroglioma and anaplastic oligodendroglioma, most of oligodendroglioma and anaplastic oligodendroglioma arise in adults, with peak incidence in patients aged 30–50 years. f The diagnosed age boxplot figure of oligodendroglioma and anaplastic oligodendroglioma. g Cumulative age distribution of Oligoastrocytoma and anaplastic oligoastrocytoma, the median ages of patients with oligoastrocytoma are 34.0 years. The median age of patients with anaplastic oligoastrocytoma is 42.5 years. h The diagnosed age boxplot figure of oligoastrocytoma and anaplastic oligoastrocytoma