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. 2020 Aug 20;18:130. doi: 10.1186/s12964-020-00615-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Cellular and exosome miRNA profiles after SRSF1 knockdown in PANC-1 cells. a Detection of SRSF1 knockdown by shRNAs in PANC-1 cells. b PANC-1 SRSF1 protein levels in nuclear and cytoplasmic fractions (NC: normal control). c Venn Diagram of overlap of miRNAs detected by next generation small RNA sequencing in SRSF1 knockdown and control PANC-1 cells and exosomes. d Heatmap showing the expression of top 25 exosome miRNAs in cells and exosomes after SRSF1 knockdown. e qRT-PCR analysis of miR-1246, miR-320c and miR-320d in exosomes derived from control and SRSF1 knockdown PANC-1 cells (*p < 0.001, Student’s t-test). Shown are representatives of three independent experiments (a-e)