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. 2020 Aug 20;53:35. doi: 10.1186/s40659-020-00302-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — The activation of HIF-1α reduced the pro-inflammation effects of Circ 0001723 down-regulation on inflammation in vitro model of SCI. HIF-1α, NLRP3 and Caspase-1 protein expression by western blot analysis (a–c) and statistical analysis (D), TNF-α (e), IL-1β (f), IL-6 (g) and IL-18 (h). Negative, negative control group; 0001723 inhibitor, down-regulation of Circ 0001723 group; 0001723 inhibitor + HIF-1α, down-regulation of Circ 0001723 and over-expression of HIF-1α group. **p < 0.01 compared with negative control group, ^##sp < 0.01 compared with down-regulation of Circ 0001723 group