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. 2020 Aug 20;17:244. doi: 10.1186/s12974-020-01919-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — CBH induces microglial polarization toward M1 phenotype and inflammatory responses in 2VO rats after 8 weeks. a Representative dot plots of CD11b/CD45 cells detected by flow cytometry. Microglia cells within the gate were used for iNOS/Arg-1 analysis. b Representative histograms of the mean fluorescent intensity (MFI) for iNOS in sham (red) and 2VO (blue) rats. c Representative histograms of the MFI for Arg-1 in sham and 2VO rats. d Quantification of MFI for iNOS/Arg-1 from sham and 2VO rats. Bars represent the mean ± SD. n = 3, cells were pooled from 3 rats per group for a total of 3 separate experiments for each time point. *P < 0.05 vs sham group, Student’s t test. e The MFI ratio between 2VO and sham rats for the expression of iNOS/Arg-1. Bars represent the mean ± SD. n = 3, cells were pooled from 3 rats per group for a total of 3 separate experiments for each time point. *P < 0.05 vs iNOS, Student’s t test. f The mRNA expression of TNF-α in the hippocampus of 2VO rats. g The mRNA expression of IL-1β in the hippocampus of 2VO rats. h The mRNA expression of TGF-β in the hippocampus of 2VO rats. Bars represent the mean ± SD. n = 6. *P < 0.05 vs sham group, Student’s t test