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. 2020 Aug 20;6(8):e04696. doi: 10.1016/j.heliyon.2020.e04696

Figure 2.

Figure 2

Clinical and biological framework on the role of visceral fat tissue and leptin in SARS-CoV-2 infection related respiratory failure. In the left panel a non-obese infected person develops limited lung injury caused by a disbalance of ACE2-ATII. The right panel shows the baseline proinflammatory state in patients with central adiposity, in particular metabolic syndrome (syndrome X) which is enhanced by ACE2-ATII disbalance and an increase in leptin production induced by ACE2 deficiency.