Table 1.

The main NOXs in the cardiovascular system.

	Activity	Regulatory subunits/requirement for p22phox	Regulation by	Cell expression
NOX1	Inducible	NOXO1, NOXA1, Rac/yes	Post-translational modification of regulatory subunits	Vascular smooth muscle, endothelial cells
NOX2	Inducible	P47phox, p67phox, p40phox, Rac/yes	Post-translational modification of regulatory subunits	Cardiomyocytes, endothelial cells, fibroblasts, vascular smooth muscle cells, inflammatory cells
NOX4	Constitutively active	None/yes	Poldip2 and transcriptional regulation	Cardiomyocytes, endothelial cells, fibroblasts, vascular smooth muscle cells
NOX5	Low constitutive activity	None/no	Ca2+	Vascular smooth muscle and endothelial cells (absent in rodents)