Table 3.

NOX4 in vascular disease models.

NOX4 modification (vascular disease models)	Disease model	Reported outcome	Reference
Overexpression	Endothelial Dysfunction	Enhanced agonist-mediated relaxation eNOS-dependent acceleration in neovascularization in hind limb ischemia	(30, 38)
Global deletion	Hypertension	No change in BP at baseline but a protection in Ang-II mediated pressure increases	(37)
Global deletion	Endothelial dysfunction	Reduced contractile dysfunction	(14)
Global deletion	Atherosclerosis	Accelerated development in diabetic model	(34, 35)
Global deletion	Ischemia/reperfusion and Stroke	Reduction in ROS and less blood–brain barrier leakage	(39)
Global deletion	Atherosclerosis	Reduced development of the neointima	(14)