. 2019 Oct 15;1(1):R13–R25. doi: 10.1530/VB-19-0027
This work is licensed under a Table 3.
Overview of the most recent literature on TGF-β and its association with TAAD.
| Author, year | Population (n) | Subject | Findings |
|---|---|---|---|
| Wang et al., 2017 (77) | 602 | Human | Reduction in SMAD4 impairs TGF-β signalling pathway is involved in progression of TAAD |
| Scola et al., 2014 (89) | 144 | Human | TGFB2 single polymorphism is associated with TAAD in women |
| Bertoli-Avella et al., 2015 (94) | 43 | Human | TGFB3 ligand causes syndromic aortic aneurysms |
| Yang et al., 2016 (84) | 51 | Murine | Decreased TGFB receptor expression on SMC disrupt aortic wall homeostasis and cause TAAD |
| Angelov et al., 2017 (90) | 75 | Murine | Loss of TGFB receptor expression on SMC accelerated various thoracic aorta pathologies |
| Hu et al., 2015 (101) | 28 | Murine | Loss of TGFB receptor expression on SMC accelerated TAAD |
| Chen et al., 2016 (95) | 119 | Murine | TGFB inhibition in presence of angiotensin II facilitates development and rupture of TAA |