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Pre-proghrelin produced within ghrelin cells is cleaved to produce ghrelin and obestatin. Ghrelin peptide is then present in these cells as unacylated or desacyl ghrelin (DAG) or becomes acylated with an 8-carbon fatty acid side chain (shown in red ring) at Serine 3 residue by ghrelin O-acyltransferase (GOAT) to become acyl ghrelin (AG). Proteases are responsible for the degradation of AG to DAG.
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