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. 2020 Jun 3;13(4):e002797. doi: 10.1161/CIRCGEN.119.002797

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© 2020 The Authors.

Circulation: Genomic and Precision Medicine is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 4. — Comparisons of the odds ratios for the polygenic risk score (PRS) models between the Taiwanese Brugada syndrome (BrS) patients with and without SCN5A mutations. The x axis shows the ranges of PRS scores in the BrS patients, whereas the y axis shows the odds ratios on a log scale. A, The PRS model developed using the 3 single-nucleotide polymorphisms (SNPs; set 1, BrS-PRS¹⁴); (B) the PRS model was developed using the 8 SNPs from set 2 (rs6599257, rs11129801, rs10428132, rs7428167, rs7641844, and rs7430439 in chromosome 3 and rs1268070 and rs9388451 in chromosome 6); (C) the PRS model developed using the 75 SNPs (set 3). The BrS patients were divided into 2 groups based on whether they had pathogenic SCN5A mutations (blue color) or not (red color).