Table 2.
AED | CYP3A4 | CYP 2C19 | CYP 2C8/9 | CYP 2B6 | CYP 1A2 | UGT |
---|---|---|---|---|---|---|
Brivaracetam | Substrate | |||||
Carbamazepine | Substrate* | Inducer§ | Substrate# | Inducer | Substrate# | — |
Inducer§ | Inducer | Inducer | ||||
Clobazam | Substrate* | Substrate*,#,†,¶ | — | Substrate*,# | — | — |
Clonazepam | Substrate | — | — | — | — | |
Diazepam | Substrate* | Substrate* | — | — | — | Substrate† |
Eslicarbazepine | Inducer | Inhibitor | — | — | — | — |
Ethosuximide | Substrate† | — | — | — | — | — |
Everolimus | Substrate | — | — | — | — | — |
Felbamate | Substrate‡ | Inhibitor‡ | — | — | — | — |
Inducer | ||||||
Lacosamide | Substrate† | Substrate† | Substrate† | — | — | — |
Lamotrigine | — | — | — | — | — | Substrate |
Inducer‡ | ||||||
Levetiracetam | — | — | — | — | — | — |
Midazolam | Substrate* | — | — | — | — | — |
Oxcarbazepine | Substrate | Inhibitor‡ | — | — | — | Substrate |
Inducer§ | ||||||
Perampanel | Substrate¶ | — | Inhibitor ‡ | Substrate | Substrate | Inhibitor‡ |
Inhibitor‡ | Inducer‡ | Inducer‡ | ||||
Inducer‡ | ||||||
Phenobarbital | Inducer§ | Substrate | Substrate | — | — | Inducer |
Inducer | Inducer | |||||
Phenytoin | Substrate# | Substrate | Substrate | — | — | Inducer |
Inducer§ | Inducer§ | Inhibitor | ||||
Inducer | ||||||
Primidone | Substrate | Substrate | Substrate | — | — | Inducer |
(active to PB) | Inducer§ | Inhibitor | ||||
Inducer | Inducer | |||||
Rufinamide | Inducer§ | — | — | — | — | — |
Stiripentol | Substrate | Substrate | Inhibitor | Inhibitor Inducer | Substrate | |
Inhibitor | Inhibitor | Inhibitor | ||||
Inducer | Inducer | |||||
Topiramate | Inducer‡ | Inhibitor‡ | — | — | — | — |
Valproate | — | Substrate | Substrate¶ | Inhibitor | Inhibitor | |
Inhibitor‡ | Inhibitor | |||||
Vigabatrin | — | Inducer‡ | Inducer‡ | — | — | — |
Zonisamide | Substrate | Substrate# | — | — | — | — |
AED, antiepileptic drug
* Pharmacologically active metabolite
† Pharmacologically inactive metabolite
‡ Weak effect of enzyme
§ Strong effect of enzyme
¶ Major metabolic pathway
# Minor metabolic pathway