Fig. 2.

The results of joint latent class modeling (JLCM) of D-dimer trend and its association with the secondary outcome of need for mechanical ventilation are depicted. D-dimer level is expressed in units of μg/ml. The two distinct D-dimer trajectories (increasing and stable) are shown in the upper left corner. Curves depicting proportion of patients not on mechanical ventilation over time are shown in the upper-right corner. The results of Cox proportional hazards models are shown in the lower panel (* the multivariable model adjusted for age, and Charlson Comorbidity Index, as these were the only baseline characteristics different between groups). Abbreviations: CI – confidence interval; HR – hazard ratio; MV – mechanical ventilation.