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. 2020 Aug 20;32(4):537–547.e3. doi: 10.1016/j.cmet.2020.08.013

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The Dynamic Profile of Cardiac Function in the Metformin and the Non-metformin Groups

Smooth trajectories of the relative levels of CK-MB (A) and NT-proBNP (B) in the metformin and the non-metformin groups, with 95% confidence interval represented by shaded regions. The relative levels of those parameters of each participant during the follow-up duration were applied and were normalized according to the upper limits of normal range in each hospital. The dotted line represents the upper limit or lower limit of the normal value of the corresponding indicator.