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. 2020 Aug 20;36:57–64. doi: 10.1016/j.prrv.2020.08.004

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© 2020 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 2 — Novel TB vaccine strategies with example vaccines. Only vaccines that are in (or registered for) phase II or III trials are included. The colours around vaccines denote trials that have shown improved protection (green), no improvement (orange), or not discussed/no results available (yellow). H4:IC31: fusion protein of antigens 85B and TB10.4 with IC31 adjuvant H56:IC31: fusion protein of antigens 85B, ESAT-6 and Rv2660c with IC31 adjuvant M72/AS01E: fusion protein of antigen 32A and 39A with AS01E adjuvant MVA85: modified vaccinia Ankara 85A TB/FLU-04L: influenza A vectored vaccine expressing the antigens 85A and ESAT-6 MTBVAC: live attenuated M. tuberculosis strain (Euro-American lineage 4) with deletion mutations in the virulence genes phoP and fadD26 VPM1002C: live attenduated M. bovis BCG-Prague (rBCGΔureC:Hly) DAR-901: heat-killed, fragmented M. tuberculosis cultured under stress conditions MIP: heat-killed Mycobacterium indicus pranii a non-pathogenic, non-tuberculous mycobacterium approved in India as a leprosy vaccine M. vaccae: heat-killed Mycobacterium vaccae a non-pathogenic, non-tuberculous mycobacterium.