Table 1.
Clinical, histological and molecular characteristics
| Case # | Gender | Age | Familial MM | Skin color | Hair color | Eye color | MM Localization | Histology | Breslow | Clark | CDKN2A mutation | RHC variants |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F | 47 | Yes | Very fair | Red | Green/Hazel | Extremities (Lower limb) | in situ | - | I | G101W | R151C, D294H |
| F | 27 | Yes | Fair | Blond | Green/Hazel | Trunk (Back) | Malignant blue nevus | - | - | 358DelG | R160W | |
| M | 39 | No | Fair | Brown | Green/Hazel | Trunk (Back) | SSMM | 0.5 | II | G101W | R151C | |
| F | 35 | Yes | Olive | Brown | Brown | Extremities (Lower limb) | SSMM | 0.5 | II | L65P | - | |
| F | 53 | Yes | Olive | Brown | Green/Hazel | Extremities (Lower limb) | in situ | - | I | G101W | - | |
| M | 46 | Yes | Very Fair | Red | Green/Hazel | Extremities (Lower limb) | SSMM | 0.5 | II | G101W | R151C (homozygous) | |
| M | 52 | Yes | Fair | Brown | Brown | Trunk (Back) | SSMM | 0.5 | II | R87W | - | |
| F | 23 | Yes | Very Fair | Red | Green/Hazel | Extremities (Lower limb) | in situ | - | I | G101W | R160W, R151C | |
| M | 35 | Yes | Fair | Red | Green/Hazel | Trunk (Lateral thorax) | in situ | - | I | 358DelG | R160W |