TABLE 2. Reported serum laboratory values for multisystem inflammatory syndrome in children (MIS-C) cases (N = 570), by latent class analysis (LCA) group* — United States, March–July 2020.
| LCA class 1 |
LCA class 2 |
LCA class 3 |
p-value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Laboratory test | No. | Median | IQR | No. | Median | IQR | No. | Median | IQR | |
| Fibrinogen, peak (mg/dL) |
151 |
557 |
(449–713) |
87 |
566 |
(430–662) |
105 |
546 |
(426–681) |
0.67 |
| D-dimer, peak (mg/L) |
158 |
3.0 |
(1.6–4.9) |
106 |
2.6 |
(1.2–5.1) |
128 |
1.7 |
(0.8–3.2) |
<0.01 |
| Troponin, peak (ng/mL) |
162 |
0.09 |
(0.02–0.48) |
109 |
0.05 |
(0.01–0.30) |
130 |
0.01 |
(0.01–0.08) |
<0.01 |
| BNP, peak (pg/mL) |
53 |
1,321 |
(414–2,528) |
30 |
198 |
(76–927) |
25 |
182 |
(30–616) |
<0.01 |
| proBNP, peak (ng/L) |
103 |
4,700 |
(1,261–13,646) |
68 |
1,503 |
(247–6,846) |
92 |
507 |
(176–2,153) |
<0.01 |
| CRP, peak (mg/L) |
166 |
21 |
(14–29) |
122 |
16 |
(9–25) |
144 |
14 |
(6–23) |
<0.01 |
| Ferritin, peak (ng/mL) |
159 |
610 |
(347–1,139) |
108 |
422 |
(207–825) |
132 |
242 |
(116–466) |
<0.01 |
| IL-6, peak (pg/mL) |
54 |
65 |
(24–258) |
27 |
41 |
(21–131) |
29 |
69 |
(7–118) |
0.24 |
| Platelets, nadir (103 cells/μl) |
115 |
131 |
(102–203) |
76 |
172 |
(103–245) |
68 |
150 |
(113–237) |
0.15 |
| Lymphocytes, nadir (cells/μl) | 72 | 695 | (400–1,093) | 49 | 1,200 | (790–2,025) | 42 | 1,420 | (723–2,250) | <0.01 |
Abbreviations: BNP = brain natriuretic peptide; CRP = C-reactive protein; IL-6 = Interleukin-6; IQR = interquartile range.
* Latent class analysis (LCA) is a statistical modeling technique in which observations can be classified into latent classes based on their underlying similarities. Variables that are associated with MIS-C clinical manifestation were selected as indicator variables and included in the LCA model.