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. Author manuscript; available in PMC: 2021 Jun 21.
Published in final edited form as: Neurosci Lett. 2020 May 11;730:135027. doi: 10.1016/j.neulet.2020.135027

Table 2:

Diseases and functions related to top 10 networks from interaction analyses

Score Brain region Network functions
47 PFC Cell Morphology, Cellular Assembly and Organization, Connective Tissue Disorders
44 MA Cell-To-Cell Signaling and Interaction, Molecular Transport, Small Molecule Biochemistry
38 MA Behavior, Neurological Disease, Psychological Disorders
37 PFC Embryonic Development, Organ Development, Organismal Development
36 LA Cell Morphology, Cellular Assembly and Organization, Cellular Development
35 MA Amino Acid Metabolism, Embryonic Development, Organismal Development
35 MA Cell-To-Cell Signaling and Interaction, Nervous System Development and Function, Organismal Injury and Abnormalities
34 MA Connective Tissue Disorders, Inflammatory Disease, Organismal Injury and Abnormalities
32 MA Auditory and Vestibular System Development and Function, Auditory Disease, Connective Tissue Development and Function
32 LA Amino Acid Metabolism, Carbohydrate Metabolism, Drug Metabolism

All networks contain 35 molecules. The network score, calculated by IPA, is equal to the - log(Fisher’s exact test result) of the chance of getting the number of DEGs from our dataset found within the network versus randomly selecting 35 molecules. For example, in Network 1, 23 of the 35 molecules are significantly differentially expressed in our dataset, resulting in a rank of 47, or a Fisher’s exact test result of 1×10−47. The ranks are calculated separately for each network and the top 10 ranked networks from interaction analyses from each brain region are shown above.