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. Author manuscript; available in PMC: 2020 Aug 20.
Published in final edited form as: Psychopharmacology (Berl). 2006 Nov 10;190(2):145–155. doi: 10.1007/s00213-006-0610-1

Figure 3. Time course effects of R(+)-nornicotine (3.0 and 5.6 mg/kg) and S(-)-nornicotine (5.6 and 10 mg/kg) pretreatment given either 15, 60, 120 or 240 min prior to the S(-)-nicotine self-administration session.

Figure 3.

Data are expressed as mean (± SEM) number of S(-)-nicotine infusions as a percent change from the baseline control (no pretreatment). The mean (± SEM) number of S(-)-nicotine infusions for the baseline control was 18.6 ± 1.4 and 16.8 ± 1.7 for the 5.6 mg/kg doses of R(+)-nornicotine and S(-)-nornicotine groups, respectively. The mean (± SEM) number of S(-)-nicotine infusions for the baseline control was 15.9 ± 1.0 and 13.6 ± 1.0 for the 3.0 mg/kg dose of R(+)-nornicotine and the 10 mg/kg dose of S(-)-nornicotine groups, respectively. The mean (± SEM) numbers of nicotine infusions earned following pretreatment with 5.6 mg/kg dose of R(+)-nornicotine at 15, 60, 120 and 240 following pretreatment were 2.4 ± 0.8, 4.8 ± 1.1, 11.4 ± 2.4, 13.6 ± 1.1, respectively. The mean (± SEM) numbers of nicotine infusions earned following pretreatment with 5.6 mg/kg dose of S(-)-nornicotine at 15, 60, 120 and 240 min following pretreatment were 10.3 ± 1.1, 11.9 ± 1.6, 14.3 ± 1.8, 14.3 ± 2.1, respectively. The mean (± SEM) numbers of nicotine infusions earned following pretreatment with 3.0 mg/kg dose of R(+)-nornicotine at 15, 60, 120 and 240 following pretreatment were 9.8 ± 1.6, 13.0 ± 2.4, 13.7 ± 1.8, 14.8 ± 1.4, respectively. The mean (± SEM) numbers of nicotine infusions earned following pretreatment with 10 mg/kg dose of S(-)-nornicotine at 15, 60, 120 and 240 min following pretreatment were 3.7 ± 1.2, 4.3 ± 1.4, 6.7 ± .76, 8.2 ± 1.5, respectively. *denotes a significant difference from control, p < 0.05. (N = 6 – 7/group).