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. 2020 Aug 18;16:1744806920950866. doi: 10.1177/1744806920950866

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© The Author(s) 2020

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — The effects of BT44 in rats with experimental neuropathy induced by SNL. Baseline was measured before surgery which was performed two days before the first drug administration. Rats received BT44 or vehicle subcutaneously once daily on days 0, 2, 4, 6, and 8 after behavioral tests (black stripes) (a). Panel (b) shows thresholds (g) to mechanical stimulation and panel (c) cold responses to acetone (positive responses/five trials) in the SNL animals treated with vehicle, 12.5 or 25 mg/kg of BT44. Panel (d) shows the area under curve of the cold response–time curve normalized to day 0 values for each group. Data in (b) and (c) represent mean ± SEM. *P < 0.05, **P < 0.01 (two-way ANOVA with Dunnett’s multiple comparison test: reference the corresponding vehicle-group without the BT44 treatment). n = 7–10. d: days; VEH: vehicle; BL: baseline; AUC: area under curve.