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Metformin prescription steps in first line.
| Metformin | ||
|---|---|---|
| Form | Immediate release | Extended release |
| Initial dose | 500-1000 mg/day | 500 mg/day |
| Titration | 500 mg every 10-15 day | 500 mg every 10-15 day |
| Optimum dose | 2000 mg/day There is evidence that 3000 mg/day may have extra benefit |
2000 mg/day |
