FIG 4.

Scnn1b-Tg mice carry higher bacterial burdens when infected with CF P. aeruginosa isolates. Scnn1b-Tg and wild-type mice were intranasally infected with the CF isolate CF001, CF002, or CF1188 and sacrificed on day 7 postinfection. Bars represent geometric means with 95% confidence intervals. CFU values were log transformed and analyzed using two-tailed unpaired t tests (CF001 data are from 2 independent infections with 16 Scnn1b-Tg mice and 16 wild-type mice; CF002 data are from 1 infection with 9 Scnn1b-Tg mice and 7 wild-type mice; CF1188 data are from 1 infection with 6 Scnn1b-Tg mice and 8 wild-type mice). The limit of detection is 100 CFU/g of lung. ***, P < 0.001.