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. 2020 Aug 20;1(6):e245–e253. doi: 10.1016/S2666-5247(20)30115-4

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© 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Tissue tropism of SARS-CoV-2 in post-mortem samples

Fresh tissues were collected from a subset of post-mortem examinations and viral load quantified by use of qRT-PCR targeting the viral E gene (A). Detection of viral RNA was verified by use of qRT-PCR against the viral polymerase gene (data not shown). Tissues were additionally tested for subgenomic viral RNA transcripts (B). Dotted lines indicate the limit of detection as ascertained by negative control. Data are included for a 61-year-old man (PM1), a 64-year-old man (PM2), a 69-year-old woman (PM3), a 78-year-old man (PM4), and a 22-year-old man (PM5). qRT-PCR=quantitative RT-PCR. SARS-CoV-2=severe acute respiratory syndrome coronavirus 2.