Table 1.

Glossary

Term	Definition
Insulin clearance	Hepatic and extrahepatic removal of insulin
Hepatic insulin clearance	Removal of a portion of secreted insulin by the liver during the first pass across portal circulation and later on during recirculation
Extrahepatic insulin clearance	Removal of a portion of secreted insulin by organs and tissues other than the liver
Insulin extraction	The fractional amount (%) of secreted insulin that undergoes removal, which can be either hepatic (HE) or extrahepatic; the corresponding clearance component is proportional to it