Table 1. Electrophysiological properties of the three Sst neuron subtypes in the VTA.
| General | ADP (n = 215) | HFF (n = 92) | Delayed (n = 85) |
|---|---|---|---|
| Input resistance (MΩ) | 783 ± 24 | 835 ± 37 | 928 ± 42 |
| RMP (mV) | −69.9 ± 0.6 | −67.8 ± 0.8 | −64.9 ± 1.0 |
| Cm (pF) | 13.2 ± 0.2 | 12.4 ± 0.3 | 15.0 ± 0.4* |
| Sag | 0.963 ± 0.002 | 0.952 ± 0.002* | 0.961 ± 0.003 |
| 1 st spike at rheobase current | |||
| Rheobase current (pA) | 18.4 ± 1.0 | 11.9 ± 1.2 | 40.8 ± 4.3* |
| AP threshold (mV) | −31.1 ± 0.3 | −31.7 ± 0.5 | −25.6 ± 0.6 |
| AP amplitude (mV) | 95.2 ± 0.6 | 94.0 ± 0.8 | 87.9 ± 0.8* |
| ADP amplitude (mV) | 13.8 ± 0.5* | no ADP | no ADP |
| 1 st AP delay (ms) | 218 ± 10 | 182 ± 14 | 528 ± 25* |
| AP half-width (ms) | 1.01 ± 0.01* | 0.90 ± 0.02* | 1.46 ± 0.04* |
| AHP amplitude (mV) | 26.3 ± 0.5 | 35.7 ± 0.9* | 25.3 ± 1.5 |
| AP decay (ms) | 2.2 ± 0.1 | 1.84 ± 0.04 | 7.9 ± 0.5* |
| Spike count | 2.1 ± 0.1* | 3.9 ± 0.2* | 1.4 ± 0.1* |
| Saturated level of excitation | |||
| Saturating current step (pA) | 207 ± 5 | 209 ± 11 | 242 ± 12 |
| Fmax initial (Hz) | 108 ± 3 | 129 ± 5 | 46 ± 15* |
| Fmax steady state (Hz) | 25.6 ± 1.1 | 42.9 ± 3.7 | 21.2 ± 1.4 |
| Adaptation ratio | 0.28 ± 0.02 | 0.32 ± 0.02 | 0.80 ± 0.04* |
| 1 st AP delay (ms) | 24.8 ± 3.4 | 12.2 ± 1.2 | 279.0 ± 20.4* |
| AP half-width (ms) | 1.88 ± 0.04* | 1.6 ± 0.1* | 2.5 ± 0.1* |
| Spike count | 21.6 ± 0.9* | 39.1 ± 3.1* | 11.00 ± 0.8* |
Data are shown as means ± SEM. Asterisks indicate values statistically different from two others (p<0.05). Row colors indicate important features, which influenced unsupervised clustering (Figure 3a–b).