Skip to main content
. 2020 Aug 4;9:e59555. doi: 10.7554/eLife.59555

Figure 8. CLC-7 mutations associated with osteopetrosis and lipid storage disease.

Figure 8.

Structure of hsCLC-7/OSTM1 colored by domain with PI3P and ATP shown as green and red sticks, respectively. Spheres represent residues with disease-causing mutations. Wheat spheres represent residues with buried side chains, orange spheres represent residues at inter-domain interfaces, green spheres represent residues near the PI3P binding site, blue spheres represent residues at transmembrane-CBS-domain interfaces and red spheres represent residues near the ATP-binding site.