Key resources table.

Reagent type (species) or resource	Designation	Source or reference	Identifiers	Additional information
Gene (Gallus gallus)	ggCLC-7	Synbio technologies
Gene (Homo sapiens)	hsCLCN7	Synbio technologies
Gene (Homo sapiens)	hsOSTM1	Synbio technologies
Cell line (Homo sapiens)	HEK-293T	ATCC	CRL-3216 RRID:CVCL_0063
Cell line (Homo sapiens)	HEK-293S GnTi-	ATCC	CRL-3022
Chemical compound, drug	Polyethylenimine, Linear, MW 25000, Transfection Grade (PEI 25K)	Polysciences, Inc	23966–1
Chemical compound, drug	Sodium Butyrate	Sigma	8451440100
Chemical compound, drug	Valproic acid	Sigma	P4543
Chemical compound, drug	Lauryl maltose neopentyl glycol	Anatrace	NG310
Software, algorithm	MotionCor2	Zheng et al., 2017	RRID:SCR_016499
Software, algorithm	CtfFind 4.1.10	Rohou and Grigorieff, 2015	RRID:SCR_016731
Software, algorithm	RELION 3.1	Scheres, 2016	http://www2.mrc-lmb.cam.ac.uk/relion RRID:SCR_016274
Software, algorithm	SerialEM	Mastronarde, 2005	RRID:SCR_017293
Software, algorithm	cryoSPARC v2	Structura Biotechnology	https://cryosparc.com/ RRID:SCR_016501
Software, algorithm	PHENIX	Liebschner et al., 2019	https://www.phenix-online.org/ RRID:SCR_014224
Software, algorithm	COOT	Emsley et al., 2010	https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/ RRID:SCR_014222
Software, algorithm	PyMOL	Schrödinger LLC, 2020	https://pymol.org/2/ RRID:SCR_000305
Software, algorithm	MOLE	Pravda et al., 2018	https://mole.upol.cz RRID:SCR_018314
Software, algorithm	UCSF Chimera	Pettersen et al., 2004	https://www.cgl.ucsf.edu/chimera RRID:SCR_004097
Software, algorithm	Blocres/Bsoft	Heymann
Software algorithm	Jalview	Waterhouse et al., 2009	https://www.jalview.org RRID:SCR_006459
Others	QUANTIFOIL R1.2/1.3 holey carbon grids	Quantifoil
Others	FEI Vitrobot Mark IV	FEI Thermo Fisher