TABLE 2.

Compounds affected by the administration of progesterone. Compounds that narrowly missed statistical cutoff for significance 0.05 < P < 0.10 are also displayed. If the ratio of means time 2/time 1 is less than 1, then the compound was found in higher concentrations during gonadal suppression than after progesterone add-back

		Time ANOVA for the whole sample		Ratio of means time 2/time 1		Time ANOVA in cases		Time ANOVA in controls
Biochemical	Pathway	P-value	Q-value	In cases	In controls	P-value	Q-value	P-value	Q-value
Alanine Aspartate	Alanine and aspartate metabolism	0.175 0.020	0.537 0.187	0.96 0.77	0.75 0.63	0.908 0.230	0.989 0.858	0.030 0.017	0.153 0.126
Glutamine	Glutamate metabolism	0.014	0.139	0.68	0.78	0.123	0.858	0.029	0.153
Threonine	Glycine, serine and threonine metabolism	<0.001	<0.001	0.79	0.64	0.004	0.357	<0.001	<0.001
Histamine	Histidine metabolism	0.001	0.018	0.79	0.75	0.041	0.742	0.002	0.027
Histidine		0.343	0.661	1.02	0.88	0.768	0.989	0.041	0.173
Isobar 6 valine, betaine	Leucine, isoleucine and valine metabolism	0.397	0.661	1.07	0.85	0.567	0.979	0.025	0.142
Alpha- aminoadipic acid	Lysine metabolism	0.107	0.422	0.84	0.84	0.455	0.944	0.078	0.255
Glutarate		<0.001	0.007	0.62	0.58	0.023	0.742	<0.001	0.010
Lysine		<0.001	0.007	0.89	0.84	0.036	0.742	<0.001	0.004
N(‘6)-trimethyl-L- lysine		<0.001	0.008	0.90	0.71	0.240	0.858	<0.001	0.000
Methionine	Methionine, cysteine, SAM and taurine metabolism	0.024	0.208	1.02	0.78	0.687	0.989	0.001	0.020
Alpha-4- dihydroxyben zenepropanoic acid	Phenylalanine and tyrosine metabolism	0.003	0.055	0.92	0.88	0.110	0.858	0.003	0.035
Thyroxine		0.206	0.576	0.81	1.47	0.834	0.989	0.015	0.113
Tyramine		0.069	0.354	0.72	0.73	0.315	0.877	0.078	0.255
Tyrosine		0.093	0.401	1.05	0.82	0.671	0.989	0.001	0.017
5-Hydroxy- indoleacetate	Tryptophan metabolism	0.018	0.169	0.79	0.88	0.069	0.749	0.104	0.281
3-Indoxyl sulfate		0.038	0.284	0.87	0.84	0.224	0.857	0.054	0.212
Serotonin		0.172	0.537	0.94	0.89	0.644	0.989	0.084	0.259
Arginine N(5)- (aminocarbonyl)- L-ornithine	Urea cycle; arginine and proline metabolism	<0.001 0.004	0.003 0.062	0.85 0.63	0.73 0.81	0.036 0.008	0.742 0.447	<0.001 0.186	<0.001 0.369
Proline		0.009	0.102	0.85	0.83	0.096	0.841	0.024	0.142
Urea adductof isobar 6		0.002	0.048	0.99	0.76	0.051	0.749	0.008	0.084
Cl adductof uric acid		0.003	0.055	0.68	0.73	0.063	0.749	0.009	0.089
Hydroxyproline form of bradykinin		0.014	0.139	0.78	0.71	0.382	0.925	0.002	0.032
Trans-4- hydroxyproline		<0.001	0.008	0.88	0.60	0.228	0.858	<0.001	<0.001
Citric acid	TCA cycle	0.095	0.403	0.83	0.81	0.396	0.926	0.085	0.259
2-deoxy-D-ribose	Pentose metabolism	0.056	0.334	1.32	1.02	0.052	0.749	0.567	0.530
Xylitol		0.049	0.320	0.79	0.77	0.335	0.881	0.037	0.162
Alpha-D-ribose 5-phosphate	Pentose phosphate pathway	0.431	0.683	1.03	0.83	0.834	0.989	0.097	0.280
Pyridoxamine	Vitamin B6 metabolism	<0.001	0.011	0.82	0.93	0.001	0.192	0.075	0.255
Isobar 2 amino- butyrates	Pyrimidine metabolism, Thymine containing	0.002	0.032	0.84	0.79	0.068	0.749	0.002	0.031
L-carnosine	Dipeptide derivative	0.173	0.537	1.02	0.88	0.972	0.996	0.022	0.142
Gamma-L- glutamyl-L- glutamine	Gamma-glutamyl amino acid	0.025	0.215	0.91	0.73	0.332	0.881	0.011	0.096
Gamma-L- glutamyl-L- tyrosine		0.246	0.616	1.14	0.83	0.465	0.944	0.004	0.037
Tartarate	Food component/plant	0.008	0.096	0.74	0.77	0.117	0.858	0.014	0.113

ANOVA, analysis of variance; time 1, after gonadal suppression; time 2, after progesterone add-back; TCA, tricarboxylic acid.

In bold: P ≤ 0.05 and Q < 0.1.